服务特色Our service：

1，含特殊氨基酸的多肽：非天然氨基酸、D-构型氨基酸、N-甲基氨基酸等

Peptide with “special” amino acids:unnatural amino acid, D-amino acid, N-Me amino acid

2，氧酯肽的合成：根据客户要求定点将氨基酸替换为羟基酸

Depsipeptide synthesis: customized mutateamino acids to hydroxyl acid

3，环状多肽：包括N端-C端环化、N端-侧链环化、C端-侧链环化和侧链-侧链环化

Cyclic peptide: N terminal to N terminalcyclization, N terminal to side chain cyclization, C terminal to C terminalcyclization, side chain to side chain cyclization

4，多肽的修饰服务：N端酰化、C端酰氨化; 荧光标记肽;生物素标记肽;磷酸肽;聚乙二醇修饰;同位素标记等

Peptide modification: N terminal acylation,C terminal amidation, fluorescent labelled peptide, biotin labelled peptide,phosphorylatedpeptide and PEG modified peptide.Isotope labelled peptide

5，固相合成结合液相合成制备结构极其复杂的多肽及其衍生物

Synthesize complex peptide and derivativesby employing the combination of solid phase synthesis and solution phasesynthesis.

6，可要据客户需要提供多肽的各种盐

Customized synthesize different peptidesalt.

所有产品均提供质量和纯度报告。

All product has quality and purity report.

Our Chemist’s work：

例如：

•       世界上唯一的选择性小分子G_q蛋白抑制剂，并对某些肿瘤具有抑制作用。

The first andonly selective Gq protein inhibitor, able to inhibit several tumor cells..

•       曾悬赏十万美元求购1毫克合成的YM-254890，全世界数百科学家参与，无人成功。

Worldwidecompetition for synthesizing 1 mg YM-254890 with 100,000 ＄ bonus, no success.

•       分子结构中含有非天然氨基酸：N-甲基丙氨酸、N-甲基脱氢丙氨酸、D-苯基乳酸、N,O-二甲基丝氨酸、β-羟基异亮氨酸。

Unnatrual aminoacids: N-Me-alanine, N-Me-dehydroanaline, D-phenyllactic acid,N,O-Me₂-threonine, β-hydroxy-isoleSucine

•       合成难点Challenge:

N-甲基化肽键N-Methylated peptide bond：比普通肽键难形成difficult to acylate.

N-甲基脱氢丙氨酸：双键难形成，且不稳定，容易受到亲核试剂的进攻

N-Me-dehydroanaline:generation of C=C bond, which is unstable and easily be attacked by nucleophies

酯键：难形成，且稳定性不好Ester bond: difficult to form and unstable

分子的环化位点的选择对于合成至关重要: proper cyclization site is crucial forthe synthesis